bio-logic（生物逻辑）

Bio-Logic: Scientific Reasoning Evaluation

Use structured frameworks to evaluate scientific claims, methodology, and evidence strength.

Instructions

1. Identify the task (claim assessment, paper critique, study design review).
2. Apply the relevant checklist below.
3. Structure output using the provided format.

Critique Checklist

Use relevant sections based on the review scope. Skip items not applicable to the study type.

## Methodology
- [ ] Design matches research question (causal claim → RCT needed)
- [ ] Sample size justified (power analysis reported)
- [ ] Randomization/blinding implemented where feasible
- [ ] Confounders identified and controlled
- [ ] Measurements validated and reliable

## Statistics
- [ ] Tests appropriate for data type
- [ ] Assumptions checked
- [ ] Multiple comparisons corrected
- [ ] Effect sizes + CIs reported (not just p-values)
- [ ] Missing data handled appropriately

## Interpretation
- [ ] Conclusions match evidence strength
- [ ] Limitations acknowledged
- [ ] Causal claims only from experimental designs
- [ ] No cherry-picking or overgeneralization

## Red Flags
- [ ] P-values clustered just below .05
- [ ] Outcomes differ from registration
- [ ] Correlation presented as causation
- [ ] Subgroups analyzed without preregistration

Claim Assessment

1. Identify claim type (causal, associational, descriptive).
2. Match evidence to claim type.
3. Check logical connection between data and conclusion.
4. Ensure confidence matches evidence strength.

Claim strength ladder:

Output Format

## Summary
[1-2 sentences: What was studied and main finding]

## Strengths
- [Specific methodological strengths]

## Concerns
### Critical (threaten main conclusions)
- [Issue + why it matters]

### Important (affect interpretation)
- [Issue + why it matters]

### Minor (worth noting)
- [Issue]

## Evidence Rating
[GRADE level: High/Moderate/Low/Very Low with justification]

## Bottom Line
[What can/cannot be concluded from this evidence]

Quick Reference

Input Requirements

• Manuscript or study summary
• Claim statements to evaluate
• Methods and results (as available)

Output

• Structured critique with strengths, concerns, and evidence rating
• Clear recommendation on claim strength and limitations

Quality Gates

• Claim type matches evidence type
• Key methodological risks are identified
• Evidence rating is justified with concrete issues

Examples

Example 1: Quick Paper Critique

Input: "Review this RCT on vitamin D and depression"

Output:

## Summary
RCT of 200 adults testing vitamin D supplementation for depression over 12 weeks.

## Strengths
- Randomized, double-blind, placebo-controlled
- Validated depression scale (PHQ-9)
- Adequate power analysis

## Concerns
### Critical
- 35% dropout, differential by group (attrition bias)
- ITT analysis not performed

### Important
- Single-site limits generalizability

## Evidence Rating
Moderate (downgraded from high due to attrition bias)

## Bottom Line
Suggestive but not conclusive due to differential attrition.

Example 2: Claim Assessment

Input: "This study proves that coffee prevents Alzheimer's"

Assessment: If based on observational data, this is a correlation→causation error. Appropriate language: "Coffee consumption is associated with lower Alzheimer's risk."

Troubleshooting

Issue: Insufficient methods details Solution: Request missing design/statistics information before rating evidence.

Issue: Conflicting results across studies Solution: Report uncertainty and suggest stronger study designs for resolution.